Calcific Aortic Valve Stenosis: Methods, Models, and Mechanisms
نویسندگان
چکیده
منابع مشابه
Mechanisms of Angiogenesisand Lymphangiogenesis in Calcific Aortic Valve Stenosis
Aortic valve stenosis (AVS) is the most common valvular disease in Western countries. Pharmacological prevention of AVS having proved unsuccessful, its current treatment is still valve replacement. The etiology of AVS is multifactorial, both genetic and external risk factors predisposing to the active pathological process eventually leading to clinically manifest stenosis. Histological features...
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T wo main causes of aortic stenosis are rheumatic involvement of the valve, observed primarily in developing countries, and calcification of the valve (calcific aortic stenosis, CAS) without the apparent involvement of an infective process. The latter is thought of as a chronically progressive “degenerative” disease of calcium deposition and subclinical inflammation akin in nature to atheroscle...
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The classic case of aortic stenosis is a healthy middle-aged patient with/without symptoms, but in practical life, patients with severe calcific aortic valve come with several and severe comorbidities such as advanced age, coronary artery disease, atherosclerotic aorta, significant left ventricular dysfunction. Aortic valve replacement (AVR) is the only options in these patients, and it require...
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In 1958 Dr. Edward C. Heyde, an internist living and working in Vancouver, WA, first reported in a letter to the New England Journal of Medicine, 10 cases of calcific aortic stenosis and grastrointestinal bleeding. The association between severe calcific aortic stenosis and iron deficency anemia due gastrointestinal bleeding, from colonic angiodysplasia was described as Heyde syndrome. A letter...
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Calcific aortic valve disease (CAVD), once thought to be a degenerative disease, is now recognized to be an active pathobiological process, with chronic inflammation emerging as a predominant, and possibly driving, factor. However, many details of the pathobiological mechanisms of CAVD remain to be described, and new approaches to treat CAVD need to be identified. Animal models are emerging as ...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2011
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.110.234138